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Dose-dependent changes in lipid parameters were observed in repeat-dose toxicology studies, whereas changes in total circulating thyroid hormones levels were observed at supratherapeutic exposures

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6 August 2020

Structure and Role Think of glutathione as a simple molecule with a complex job

Gclm KO mice are viable 17,18 , having 1540% of normal tissue GSH levels due to GCLC expression

Therapeutic strategies under investigation include partial agonists (e.g., D -cycloserine) and modulators of the glycine co-agonist site, which may enhance plasticity while minimizing toxicity