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This is also suggested by the overexpression of the chaperon GRP78/BiP, which appears to play an important role in the mobilization of Ca 2+ from the ER to the mitochondria 50,55

Arch Gynecol Obstet 303(1):1725

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Within the companys broader cardiometabolic pipeline, this package underscores AstraZenecas intent to develop elecoglipron as a comprehensive oral GLP1 therapy for type 2 diabetes and chronic weight management, with Phase IIb success now providing the basis for planned Phase III evaluation