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Certain microbes have been identified to express TMA lyases, including the commonly reported choline TMA lyase (cutC/D), carnitine Rieske oxygenase/reductase (cntA/B), betaine reductase, TMAO reductase (TMAOase), ergothionase, and -butyrobetaine utilizing enzyme (Gbu) [1820, 22, 23]

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Here, Ozempic is an ideal GLP-1 analog, as it produces long-lasting effects that are more pronounced than the natural hormone