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Of the four receiving combination therapy, three reported improvement

A third widely-cited paper (McCoy 2013, PMID 23055539) the source of the often-repeated "seven orders of magnitude more potent than BDNF" line carries a 2021 Expression of Concern

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Currently, there are several medications in the pipeline that are being investigated for chronic weight management, some showing fairly robust safety and efficacy profiles

Kitz R, Wilson IB (1962) Esters of methanesulfonic acid as irreversible inhibitors of acetylcholinesterase