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The mechanism of action involved inhibition of sphingosine kinase 1 (SphK1), a sphingosine-1-phosphate (S1P)-producing enzyme, along with STAT3 and NF-Bp65, which are involved in chemokine production [91]

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Histologically, when compared to control kidneys, Ire1-null kidneys had significantly reduced tubular damage quantified by tubular dilation, brush border loss, flattened epithelial cells or sloughing of cells and tubular cast formation after IRI (Fig