Incretin-based multi-agonists, such as tirzepatide and retatrutide, target two or more receptors among GLP-1, GIP, and GCGR to enhance insulin secretion, improve fat metabolism, and increase energy expenditureultimately achieving greater weight loss and metabolic improvement
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As a next-generation triple-action peptide, it works by targeting GLP-1, GIP, and glucagon receptors togetherthree critical pathways in metabolism
Finally, 70 studies met the selection criteria for qualitative analysis (eTable 2 & 3 in the Supplement) and 47 studies for quantitative synthesis (eTable 4 in the Supplement and Fig
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Periodontal disease: the sixth complication of diabetes mellitus
