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In clinical trials, semaglutide (Wegovy) patients lost an average of ~15% of body weight over 68 weeks

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On the other hand, no significant differences in active GLP-1 and GIP were noted in plasma isolated immediately in the same mice by CP (Figure 2, E and F)

The boxed thyroid tumor warning, rare pancreatitis, gallbladder disease, and other risks apply regardless of dose, and some are contraindications