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MiR-34a upregulation suppressed SUI in IL-1-treated FVWFs by increasing collagen and TIMP-1, lowering MMP-2 and MMP-9, and blocking nicotinamide phosphoribosyltransferase (Nampt) transcription, which accelerated autophagy and suppressed ECM breakdown (Zhou et al

The Calu3 cell line is the most widely used model to reproduce the upper respiratory epithelium, as it is able to recapitulate differences in mucus layer thickness and cytokine production when grown under liquid-liquid interface (LLI) or air-liquid interface (ALI) conditions

Vitamin C: In one study, taking 500 or 1,000 mg per day of vitamin C for 13 weeks led to an increase of 18% of the glutathione levels in lymphocytes

Glutathione is a compound made naturally in the body and found inside cells

[68] Epigenetics [edit] The presence of epigenetic modifications for certain genes has been demonstrated in this type of pathology

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