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The formulation releases both the peptide and the permeation enhancer at high concentration, quickly together in the small intestine following enteric coating dissolution, enabling rapid absorption

Bassi: Prepared figures and tables, and reviewed the manuscript for clinical accuracy

Standards of Care in Diabetes2024

The retatrutide vs semaglutide comparison examines how this next-generation compound differs

[2] [3] It is administered as a once-weekly subcutaneous injection using multi-dose prefilled pens available in 0.25 mg, 0.5 mg, 1 mg, and 2 mg doses

The peptide is structurally derived from native human GLP-1(7-37) with two amino acid substitutions (Aib at position 8 for DPP-IV resistance, Arg substitution at position 34) and a C18 fatty diacid moiety conjugated via a Glu-(AEEA) linker enabling reversible albumin binding and an extended pharmacokinetic profile compatible with once-weekly dosing