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This process triggers intracellular signaling cascades, leading to increased NLRP3 expression, promotion of myocardial fibrosis, and further acceleration of the progression of atrial fibrillation

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The Cu(II)/Cu(I) redox couple generates reactive oxygen species through the Fenton-like pathway: Cu(II) + O Cu(I) + O Cu(I) + HO Cu(II) + OH + OH Hydroxyl radicals (OH) are highly reactive and immediately oxidize susceptible amino acids

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