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doi: 10.1186/1471-2407-13-214 23 LenerMMuszyskaMJakubowskaAJaworska-BieniekKSukiennickiGKaczmarekKet al

This low-grade, long-term inflammation spreads throughout the body, irritating joint linings, breaking down cartilage matrix integrity, and hyper-sensitizing local nerve pathways

Therefore, we conducted sensitivity analyses to determine whether baseline HbA 1c or prior metformin treatment were mediating factors