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Methods C57BL/6J mice and Sirt1 +/ mice were treated with exenatide (24 nmol/kg) or an NaCl solution (154 mmol/l) control i.p

Epidemiological evidence demonstrates a strong association between obesity and KOA, highlighting shared pathogenic mechanisms

Antidiabetic drugs with limited evidence for tumor risk association -Glucosidase inhibitors As an antidiabetic drug, -glucosidase inhibitors primarily act by inhibiting the breakdown of complex carbohydrates in the gastrointestinal tract, thereby slowing their absorption and mitigating postprandial hyperglycemia

In the largest pharmacogenomics GWAS of GLP-1 medications to date (15,237 participants, replicated in the All of Us cohort), researchers identified a missense variant in GLP1R the gene encoding the very receptor that semaglutide and tirzepatide bind that significantly predicts how much weight a person loses on treatment

5 , 189 (2016) Acknowledgements This work was supported by the National Natural Science Foundation of China grants 31330019 (Z.-J.L.), 31500593 (G.S.), 81373463 and 81573479 (D.Y.), the National Health and Family Planning Commission grants 2012ZX09304-011, 2013ZX09401003-005, 2013ZX09507001 and 2013ZX09507-002 (M.-W.W.), Shanghai Science and Technology Development Fund 15DZ2291600 (M.-W.W.), and Ministry of Science and Technology of China grants 2014CB910400 (Z.-J.L.) and 2015CB910104 (Z.-J.L.), the Netherlands eScience Center (NLeSC)/NWO Enabling Technologies project: 3D-e-Chem, grant 027.014.201 (C.d.G.), the European Cooperation in Science and Technology Action CM1207 GLISTEN (C.d.G.), and National Key Research and Development Program of China 2016YCF0905902 (S.Z.)

Simultaneous GLP-1 receptor activation and angiotensin receptor blockade increase natriuresis independent of altered arterial pressure in obese OLETF rats