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Patients with gout frequently have comorbid conditions that predispose to renal dysfunction and increased urate reabsorption, including hypertension and metabolic syndrome (insulin resistance) (see: Who Gets Gout?) Impaired urinary alkalinization in metabolic syndrome likely contributes to elevated risks of uric acid urolithiasis in the gout patient population

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Drug interaction note: GLP-1 receptor agonists may interact with nitrate-class medications, anticoagulants, and drugs for blood sugar management

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[DOI] [PubMed] [Google Scholar] 61.Hussein G.M., Matsuda H., Nakamura S., Hamao M., Akiyama T., Tamura K., Yoshikawa M