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Interestingly, the cases with SLC39A14 deletion appear to be more than those with amplification (Fig

A 2022 systematic review and meta-analysis published in JAMA Internal Medicine found that GLP-1 receptor agonists were associated with increased risks of biliary disease compared to other diabetes medications, with higher risk observed at weight-loss doses and with longer duration of treatment

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In addition to weight loss, participants demonstrated up to an 83% decrease in high-sensitivity C-reactive protein (hsCRP), a key marker of inflammation linked to cardiovascular risk, and a substantial increase in adiponectin, a protein hormone that supports insulin sensitivity, fat metabolism and anti-inflammatory processes