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Kadowaki T, Isendahl J, Khalid U, et al

Berberine conjugates, such as berberine-benzenediol derivatives, berberine-melatonin hybrid, and berberine-ferulic acid hybrid, exhibited anti-oxidant activity, and inhibited A aggregation

The results obtained also show a further increase in glutathione peroxidase activity in the magnesium and insulin treated diabetic groups suggesting a potentiating effect of magnesium on the activity of this enzyme in these treatment groups (Table 2)

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The parent molecule has Phase 2 human data in cardiac and ocular contexts