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Further insights into this complex crosstalk, may help us overcome some disappointing clinical results and allow the translation of novel molecules and strategies to specifically suppress the IGF-1R-induced tumor promoting effects

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Key finding: Ipamorelin increased lean body mass by 2.1kg, reduced fat mass by 2.7kg, improved body composition ratio by 18%

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Mol Cell (2008) 30:21426.10.1016/j.molcel.2008.03.003 171 GreerELOskouiPRBankoMRManiarJMGygiMPGygiSPet alThe energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor

This mechanistic distinction is the focus of ongoing preclinical research