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KD also increases calbindin activity, acting as an intracellular calcium buffer, and prevents the dissociation of the pro-apoptotic factor Bad from its chaperone 143-3, thereby stabilizing neuronal survival pathways [49]

Notably, Acsl4 deletion in siGpx4 IECs did not protect against LPO after AA exposure (Supplementary Fig

2.7 Statistical analyses StatsDirect 2.8.0 (StatsDirect Sales, Sale, Cheshire, M33 3UY, UK) and GraphPad Prism 9.5.1 (Insightful Science, California, USA) software were used for statistical processing and graphical display of data

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This naturally occurring compound plays a key role in protecting cells from oxidative stress and supporting vital organ function