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Their lack of selectivity leads to widespread adverse effects such as dry mouth, blurred vision, urinary retention, and severe constipation (fourth panel)

It is designed to begin working when your blood sugar rises, and it promotes the pancreas releasing more insulin when blood sugar levels are up

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Once reconstituted, the peptide becomes much less stable

The reported daily fluid intake decreased for patients on dulaglutide from a median (IQR) of 4500 [3625, 5000] mL to 3000 [2500, 3875] mL, while it remained constant with placebo treatment, from 4000 [4000, 5000] mL to 4000 [3500, 5000] mL