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Central administration of the TLR4 inhibitor TAK242 enhanced leptin-induced suppression of food intake in rats with diet-induced obesity, but did not exert additive effects in RYGB-treated animals, indicating that RYGB may exert its benefits through this mechanism

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doi: 10.1152/japplphysiol.01077.2006

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Theyre crafted without animal-derived ingredients, making them completely vegetarian-friendly.