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Mutations in Gli3 result in a shortened cell cycle, impaired cortical lamination, and cortical neuron formation and are responsible for various morphological CNS abnormalities, such as Greig cephalopolysyndactyly syndrome (GCPS), Pallister-Hall syndrome (PHS) and polydactyly and syndactyly (178)

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Species-specific factors profoundly influence both efficacy and safety profiles across all three peptide components

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The TOZAL [166] study also found that visual function was improved when daily use of L 8 mg for more than 6 months for patients with dry AMD

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