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Cellular Biology 33, 7184

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10.1016/j.biocel.2007.07.008 Int

Conclusion MDSCs are pivotal mediators of immune evasion in cancer, playing a dual role in both immunosuppressive and non-immunosuppressive tumor-promoting activities, such as supporting cancer stem cell survival, inducing angiogenesis, driving the epithelialmesenchymal transition, and contributing to the formation of pre-metastatic niches

Pathogenesis of autoimmune disease

Wilsons disease is the paradigmatic example: an inherited defect in the ATP7B copper-transport protein that impairs the bodys ability to remove excess copper, causing toxic copper accumulation in the liver, brain, eyes, and other organs