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Mechanistic studies indicate that CGRP promotes M2 macrophage polarization by inhibiting the p53 signaling pathway and enhances endothelial cell function, thereby accelerating DBW healing
The lipopolysaccharide (LPS) endotoxin produced by gram-negative bacteria can trigger a strong immune response, and intraperitoneal injection of LPS in rodents serves as a classic model of systemic inflammation
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Oct 21 2020;21(20)doi:10.3390/ijms21207796
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