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10.1016/j.pnpbp.2012.09.003 144 StarchenkoG.HrytsykA.RaalA.Koshovyi

This short half-life significantly impacts the efficiency of labeling after injection into a patients body, thereby limiting their clinical applications

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Kynurenine, a metabolite of tryptophan, upregulates T-cell PD-1 levels by inducing and activating the aryl hydrocarbon receptor (AhR), while AhR upregulates transporters to promote T cells to uptake kynurenine, forming a positive feedback loop and inhibiting anti-tumor immune responses (Liu et al., 2018)