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N Engl J Med 2024;391(2):109121

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10.1073/pnas.80.18.5485 80 LovicD.PiperidouA.ZografouI.GrassosH.PittarasA.ManolisA

To improve gastrointestinal tolerability, the patients assigned to the 10 or 15 mg doses of tirzepatide were up-titrated to final doses, with those in the 10 mg group receiving a 5 mg dose for the first two weeks and then a 10 mg dose for the remainder of the study, whereas the subjects in the 15 mg group were given a 5 mg dose for the first two weeks, a 10 mg dose for the next four weeks, and a 15 mg dose for the remaining study duration

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