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Harada D, Namba N, Hanioka Y, Ueyama K, Sakamoto N, Nakano Y, et al
The FDA explicitly determined that Geref (sermorelin) was not withdrawn for reasons of safety or effectiveness
Category 2: Growth Hormone Secretagogue Receptor Agonists (GHRPs and Ghrelin Mimetics) These act on the GHS-R1a (ghrelin) receptor a different receptor from GHRH to amplify GH pulse amplitude and reduce somatostatin tone
The long-acting DAC form delivers a continuous multi-day signal and cannot be timed against a pulse
[5] GHS-R1a receptors are expressed not only on pituitary somatotrophs but also in the hypothalamic arcuate nucleus, where they are co-localized with neurons involved in reproductive hormone regulation
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