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In the SURMOUNT-1 clinical trial, patients taking the highest dose (15 mg) of tirzepatide lost about 21% of their body weight over 72 weeks

In reaction to AD, astrocytes experience a shift in profile, one that is reactive and pro-inflammatory while losing homeostatic roles thus disrupting BBB integrity, ion and neurotransmitter buffering, and energy metabolism (Liddelow et al., 2017

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Efficacy is slightly reduced in those with diabetes, but participants were still able to lose 16.9% of body weight alongside a 2.16% reduction in HbA1c from baseline after 36 weeks [118]

Images were taken with an Olympus FluoView 1000 confocal microscope and subsequently analyzed by using Olympus FluoView FV1000 Software, ver