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This article is part of our series on the FDAs National Priority Voucher program, exploring the therapies selected, their potential impact, safety considerations, and what accelerated review could mean for patients in the US and globally

Karlic H, Lohninger A

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Based on the National Survey on Drug Use and Health from 2013, it was estimated that 43.8 million of all adults in the USA had any mental illness in 2012 and 10 million had serious mental illness.In 2013, 15.7 million of all adults in the USA were affected by a major depressive episode over the past 12 months (National Institute of Mental Health 2016d)

Increased calcium inside the cell activates enzymes such as caspases, calpains and nitric oxide synthase