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(PubMed) Eltom M, Elnagar B, Sulieman EA, et al

The peptide increases glutathione peroxidase, another crucial antioxidant enzyme

When to Consult Your GP or Pharmacist You should contact your GP, prescribing clinician, or pharmacist before starting ispaghula if: You have difficulty swallowing or a history of oesophageal disorders You have a narrowing or obstruction anywhere in your gastrointestinal tract You experience severe or persistent constipation despite lifestyle measures You have diabetes requiring careful monitoring, as changes in fibre intake can affect blood glucose levels You take multiple medications, particularly those with narrow therapeutic windows or known interactions with fibre supplements You have kidney disease or are on a restricted diet, as some ispaghula formulations contain sodium or potassiumcheck the label or ask a pharmacist Seek urgent medical advice if you develop: Severe, persistent abdominal pain (with or without vomiting) which could suggest pancreatitis Right-upper-quadrant pain, fever or jaundice which might indicate gallbladder problems Difficulty swallowing or breathing after taking ispaghula Chest pain or vomiting Rectal bleeding or failure to have a bowel movement after using the product Signs of dehydration (dark urine, dizziness, reduced urination) Allergic reactions such as rash, itching, or facial swelling Regular review is important for anyone taking Wegovy, as dose adjustments and monitoring for side effects are part of safe prescribing practice

Reduction in cortical parvalbumin expression due to intermittent theta-burst stimulation correlates with maturation of the perineuronal nets in young rats

We found that few women were prescribed weight loss medications during pregnancy, and fewer than 10 women (0.001%) were prescribed phentermine or a GLP-1 medication in the third trimester, as shown in Figure 1