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Weeks 5-8 at 1.5 mg per week uses 6.0 mg

Cellular and molecular mechanisms of metformin: an overview

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If you're seeing good weight loss results and feel well on a lower dose like 0.75 mg or 1.0 mg, there's no medical requirement to increase further

Even though these drugs have been extensively studied, Sharma thinks it is possible that gastroparesis is rare enough that it didnt show up in the drugs clinical trials because they didnt include enough patients