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Phase 2 trial data published in the New England Journal of Medicine (2023) demonstrated average reductions in body weight exceeding 20% over 48 weeks in some participants

The absence of GPX4 leads to spontaneous DKD development owing to tubular damage, while its upregulation reduces this damage [14]

doi: 10.1073/pnas.0804333106

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However, the experiments in the present study were not sufficient to completely elucidate the underlying mechanisms of ferroptosis in AKI through molecular and animal model experiments alone, and similarly RGSH intervention on AKI is only a meaningful first experiment

Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation