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One of the most interesting features of one carbon metabolism is that reaction velocities are often affected not just by substrate and product concentrations and enzyme activities but also by the concentrations of substrates in distant parts of the reaction network that act as allosteric activators or inhibitors of the enzyme

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There was also another study that was shown when you put all four of these factors, and just turn it on for a couple of days, you could rejuvenate a short-lived mouse, and that credit and perhaps a prize one day will be awarded to one Carlos Belmonte, at the Salk Institute