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Claim construction decisions and invalidity findings in prior cases also create estoppel and collateral estoppel issues that can directly affect the defensibility of related claims in current patents

Furthermore, the study included only active dentinal caries

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For example, the U87-MG glioma that was found resistant to CR when grown as a subcutaneous xenograft in NOD-SCID mice 63 was responsive to CR when grown orthotopically in mice of a different genetic background

Time-to-event analyses were performed on all 71 cases (8 patients from our institution and 63 patients from the literature) to assess the risk of metastasis, recurrence, and death by tumor location and type of treatment received