Moreover, senescence cells secrete many bioactive molecules collectively termed the senescence-associated secretory phenotype (SASP), which can induce chronic inflammation, alter tissue architecture, and promote tumorigenesis through paracrine signaling
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DNA methylation at CpG sites across the genome changes in systematic, age-predictive patterns that are measurable as "epigenetic age" with biological epigenetic age sometimes running ahead of or behind chronological age based on genetics, lifestyle, and metabolic health
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Bottom line: A holistic approach that combines high-bioavailability supplementation with a sulfur-rich diet and healthy sleep habits is the most effective way to maintain optimal glutathione levels
Your cells naturally recycle GSSG back into GSH, although many peoples glutathione recycling and production systems are suppressed by genetics or environmental stress, especially as we age
