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Early reports that Kupffer cell-induced oxidant stress and peroxynitrite formation may cause APAP-induced injury [92, 93] were questioned as the data could not be reproduced [9496], NADPH oxidase-deficient mice were not protected [97, 98] and mitochondria in centrilobular hepatocytes were identified as the main source of superoxide and peroxynitrite under these conditions [72, 99]

There is also a potential for creatine to improve cognitive function, however, more research is needed to prove this (Smith-Ryan et al., 2025)

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Dying to defend: neutrophil death pathways and their implications in immunity

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Protective role of sirtuin3 (SIRT3) in oxidative stress mediated by hepatitis B virus X protein expression