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This destructive oxidative process is considered a central mechanism of ferroptosis, iron overload accelerates the production of ROS via the Fenton reaction, which in turn amplifies lipid peroxidation, compromising the cell membrane and leading to ferroptosis

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There is a lack of long-term data beyond 23 months, and large-scale, randomized controlled trials are limited, according to Anetta Reszko, MD, a board-certified dermatologist and dermatologic surgeon, a clinical assistant professor of dermatology at Weill Cornell Medical College