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One possibility is that GLP-1R endocytosis is required for agonist uptake by the brain via hypothalamic tanycytes, as described for leptin 65

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[DOI] [PMC free article] [PubMed] [Google Scholar] 193.Chen Y., Li Z., Yang Q., Yang S., Dou C., Zhang T., Guan B

Like the kidneys and liver of growing pigs [31], increasing the dietary intake of glycine up-regulated the activities of creatine-synthesizing enzymes in the skeletal muscle of HSB (Table 3)

S., Novosadova M