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Later that year, however, a new observational study published in JAMA Network Open reignited the debate around the safety of the class, prompting the FDA to take another look

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Taken together, GCGR agonism offers a promising yet complex strategy in cardiometabolic disease, as it promotes weight loss and energy expenditure while also increasing blood glucose, underscoring the need for dual- and triple-agonist approaches (GLP1R/GIPR/GCGR) that balance metabolic and CV effects

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