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Different analyzers used in high resolution MS, including time of flight (TOF), and Orbitrap enable the determination of the elemental composition (assignment of the most probable sum formula) of a compound by measuring the exact mass and comparing the isotopic profile of the obtained spectrum with the theoretical profile

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Proc Natl Acad Sci U S A 83:792317927 Jones R (1990) Roles for replicative deactivation in yeast-ethanol fermentations

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