Phosphinic peptides often share structural similarities with the transition-state of peptide substrate upon hydrolysis ( Figure 11 The phosphinic group is, as compared to, e.g., thiols and hydroxamic acids more weakly binding to zinc ions in metalloproteases and a significantly improved selectivity could be achieved by systematic variations of the side chains at P1 and P2 positions of 43
S2CID 25000753
Repeated activation of the receptors can lead to upregulation and sensitization, causing hyperexcitability of the receptor even at low levels
The multiyear project was initiated by Xingya Jiang PhD19, who is now a postdoctoral research fellow at Harvard Medical School/Brigham and Womens Hospital, and was continued by Qinhan Zhou, a PhD candidate in chemistry at UT Dallas
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TM3 cells were harvested after treatment, stained with Annexin V-FITC and PI reagent, and incubated in the dark for 15 minutes