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Mechanistic rationale Botulinum toxin A cleaves SNAP-25 at a specific site, paralysing cholinergic transmission

Haroon E, Raison CL, Miller AH

Mental Focus and Mood Sticking to a weight loss plan often requires willpower

PMID 7862486

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INTRODUCTION Melasma is an acquired, chronic, and recurrent form of hypermelanosis, which is characterized by symmetrical brown macules and patches of variable darkness on sun exposed areas of the body, typically occurring on the face (lower cheeks, forehead, nose, and upper lip).[] Though the pathogenesis of melasma is unclear, factors such as genetic makeup, ultraviolet (UV) radiation, pregnancy, and hormonal therapy are known to influence the development of melasma