The method of synthesis according to claim 1, characterized in that: the base used in the coupling reaction in the step (2) is organic base or inorganic base, and the organic base is any one of triethylamine, N-diisopropylethylamine, pyridine, piperidine and aniline
Further, NRF1 has been shown to be important for the survival of hepatocytes and to mediate oxidative stress during development 62,63
Diet-induced adaptations in NTS and AP neurons are thought to contribute to the development of overeating and obesity [133, 137,138,139]
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