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On March 5, Novo Nordisk released the top-line results from this pivotal kidney outcomes trial: Use of semaglutide in patients with diabetic kidney disease reduced the primary outcomea composite of kidney failure, 50% decline in estimated glomerular filtration rate (eGFR), and cardiovascular (CV) or kidney deathby an impressive 24% (Figure 1)

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Results vary based on individual factors including age, baseline hormone levels, diet, exercise, and adherence to protocol

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STAT3 and HIF1alpha cooperatively mediate the transcriptional and physiological responses to hypoxia