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Dehydrated states impair lipolysis efficiency, potentially reducing the effectiveness of both compounds

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HR averaged over 24 h increased by 2 bpm with exenatide BID compared with a decrease of 1 bpm for placebo (n = 26) at the end of the study period [21]

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The .25 mg dose absolutely produces weight loss in most peopleit's designed as a starting point precisely because it's effective while minimizing side effects