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In: UpToDate, Connor RF (Ed), Wolters Kluwer

May support reductions in fat mass while preserving lean muscle in animal models [5] [6]

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Additionally, certain variants in genes related to antioxidant response, such as the catalase (CAT) gene and the glutathione peroxidase (GPX) gene, have been associated with increased susceptibility to vitiligo.67,69,70 Furthermore, vitiligo has been associated with defective recycling of tetrahydrobiopterin (6BH4), essential for melanin formation, leading to an excess of 7BH4 and inhibition of phenylalanine hydroxylase (PAH)