Related studies have indicated a causal relationship between IR and all clinical symptoms of PCOS, with weight loss being shown to improve the reproductive function, hyperandrogenism and metabolism of women with PCOS (155, 156)
Beyond the pancreas, GLP-1R is expressed in the brain (particularly the hypothalamus, brainstem NTS, and reward circuitry), heart, kidney, lung, gastrointestinal tract, bone, and immune cells
K.et al (2022)
Those considering discontinuing semaglutide should continue probiotics through the transition period, as the microbiome will shift again when GLP-1 signaling returns to baseline levels
The fact that patients in this trial continued to lose weight after gastrointestinal adverse effects had subsided suggests that these effects were not the cause of weight loss
NAFLD is a basic umbrella term to describe the entire spectrum of non-alcoholic fatty liver disease