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Semaglutide has a half-life of approximately one week, so GI effects diminish gradually rather than stopping immediately

More noticeable weight loss often develops over the following months as the medication continues working alongside healthy lifestyle habits

But it does mean you're accepting risks that don't exist with topical application, for benefits that may not be meaningfully greater

It functions by blocking the kidneys SGLT2 protein, which is in charge of reabsorbing glucose into the circulation

So, exercising and optimally maintaining muscle whilst losing weight is crucial