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However, as GLP-1R expression is generally absent in most tumor specimens, the anticancer effects of Ex-4 may be restricted to specific patients with ovarian cancer who also have diabetes [72]

PMID 24485345

Recent findings have indicated that levels of the atypical methyltransferase METTL1 are elevated in cancer cells, thereby promoting glutamine synthase (GLUL) expression in an m6A-dependent manner, which in turn facilitates cancer cell proliferation [44]

doi: 10.1007/s00394-020-02248-7 29 BeserraBTFernandesRdo RosarioVAMocellinMCKuntzMGTrindadeEB

263 This suggests the complex effect of lncRNAs on the IR progression