Overexpression of MDM2 results in decreased level and activity of p53 (Kubbutat et al, 1997) and provides an alternative to a p53 mutation in the sense that it inactivates p53
The temptation to escalate the dose because nothing is happening yet is exactly the mistake the timeline section is designed to head off the mechanism is cumulative, not dose-chased
Follow-up cadence is individualized and determined by the prescribing clinician
On the contrary, the potential for learning and change within institutions heavily relies on how civic action is organized, shaped, and infused with competencies and visions
2007;50(2):2508 Hataya Y, Igarashi S, Yamashita T, and Komatsu Y
Inside the cell, it is deoxygenated and reduced to Fe 2+ by iron oxide reductase