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Additionally, a diet low in folic acid or other key vitamins may also affect your body's ability to use B12 effectively

Intervention with the therapeutic drug, amifostine (AMI), can reduce DNA damage and ROS levels in cells and the ratio of RANKL to OPG, inhibit the maturation and differentiation of osteoclasts, and has a bone protective effect (222).Osteoclasts cause ROS accumulation during bone resorption or increased RANKL expression (223)

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Curr Med Chem 6:279309 Schlenk D, Handy R, Steinert S, Depledge MH, Benson W (2008) Biomarkers

It helps regulate cellular redox balance, participates in the metabolism of certain drugs and environmental compounds, and supports normal immune and mitochondrial function

Methotrexate and rheumatoid arthritis associated interstitial lung disease