Hypoglycemia risk is low with semaglutide monotherapy because its glucose-lowering effect is glucose-dependent
Gutierrez AD, Gao Z, Hamidi V, Zhu L, Saint Andre KB, Riggs K, et al
All currently approved injectable GLP-1RAs have demonstrated CV safety (non-inferiority) in CVOTs [12, 19,20,21,22,23], but only four have demonstrated both CV safety and superiority relative to standard of care [12, 20, 22, 23]
sitagliptin was DKK 95,093/QALY (12,746)
More than two dozen studies presented over the past few days at the American Society of Clinical Oncology meeting in Chicago found that patients taking the drugs showed lower risks of developing cancer and disease progression, better survival, and improved responses to some treatments, compared with people who were not taking the GLP-1s
These were not direct head-to-head trials, so the comparison should be interpreted carefully